Formulation and Evaluation of Ketoprofen Emulgels by Model Independent Approach
نویسندگان
چکیده
In the current study, ketoprofen emulgels were prepared using Sodium CMC, alginate and Hibiscus as gelling agents in order to overcome gastric side effects achieve pharmacological response. Pre formulation parameters performed know compatibility of pure drug with polymers Na alginate, hibiscus prior preparation Emulgel. It indicates that no change was observed peak values physical mixture thus providing both polymer said be compatible each other. Emulgel 2.5% w/w 3 steps i.e., Preparation gel, emulsion phases separately incorporate homogenizer for a period 45 min stabilized it 2 hrs. The evaluated characteristics, content, pH, spreadability in-vitro permeation studies. appearance all formulations creamy white, consistent, homogenous stable. pH found well within range 6-7. Release rate kinetics studied vitro data F1 F9 results stated best fit model selected F6 Zero non-fickian diffusion. compared reference product. dissolution nearest product F10 (f2 = 85.17).
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ژورنال
عنوان ژورنال: Future Journal of Pharmaceuticals and Health Sciences
سال: 2021
ISSN: ['2583-116X']
DOI: https://doi.org/10.26452/fjphs.v1i3.224